منابع مشابه
Replication of low-level carcinogenic activity bioassays.
Bioassay for carcinogenic activity of a number of epoxides, lactones, hydroperoxides, and peroxides was reported from the laboratory at New York University (2,3). The compounds were tested by skin application on mice, s.c. injection in mice and rats, and feeding and intratracheal instillation in rats. Another series of related compounds was more recently tested at Fels Research Institute by s.c...
متن کاملStructure and carcinogenic activity of azo dyes.
In recent years many investigations have been carried out on the carcinogenic activity of several groups of derivatives of 4-aminoazobenzene, their spectra, the relative basicities of their nitrogen atoms, and their metabolism (1, 2, 9, 14). The principal results on the correlation of structure and activity are as follows: Methylation.--3'-Methyl-4-dimethylaminoazobenzene is a tvery potent carc...
متن کاملThe carcinogenic activity of dihydroxybenzidine; further investigations.
fact that benzidine, in the commercial form of the free base, the sulphate, or the hydrochloride, exerts a powerful carcinogenic activity upon the human bladder has been accepted owing to the clinical evidence reported during the past @0 years However, the importance of ruling out any other compound, or combination of compounds, as the carcinogen in cases of bladder tumors found among workers i...
متن کاملCarcinogenic activity of quinoline on rat liver.
The effects of prolonged p.o. administration of quinoline or 2-chloroquinoline on rat liver were examined histologically. Hepatocellular carcinomas and hemangioendotheliomas were observed in the livers of rats fed a basal diet containing 0.05, 0.10, or 0.25% quinoline for about 16 to 40 weeks. However, no neoplastic changes were seen in the livers of rats fed a basal diet containing 0.05, 0.10,...
متن کاملMultifactor potency scheme for comparing the carcinogenic activity of chemicals.
A scheme for ranking the quantitative activity of chemical carcinogens is described. This activity scheme uses as its base dose potency measured as TD50 which after conversion into an inverse log scale, a decile scale, is adjusted by weighting factors that described other parameters of carcinogenic activity. These factors include positive or negative weightings for the induction of tumors at ti...
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ژورنال
عنوان ژورنال: Nature
سال: 1969
ISSN: 0028-0836,1476-4687
DOI: 10.1038/221391b0